Comparative studies on virulence, genetic variability and mycotoxin production among isolates of fusarium species infecting wheat (2024)

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Comparative studies on virulence, genetic variability and mycotoxin production among isolates of fusarium species infecting wheat (2024)

FAQs

What group of mycotoxins are produced by Fusarium species? ›

Fusarium species produce three important classes of mycotoxins, namely trichothecenes, fumonisins, and zearalenones with their mycoestrogens. These toxins are highly toxic and carcinogenic to farm and laboratory animals and have been associated with human esophageal cancer and birth defects [14,15].

Are mycotoxins virulence factors? ›

Recent studies have made substantial progress in the determination of mycotoxins as virulence factors. Although the pathogenicity of aspergillosis may be multifactorial [45], mycotoxins should be examined not just as a source of food contamination but also as possible virulence factors.

What is the factor affecting mycotoxin production? ›

Factors such as temperature, moisture content, and storage duration can contribute to the growth of moulds and subsequent mycotoxin production [16]. Inadequate storage conditions and poor moisture control can promote fungal growth and mycotoxin accumulation in stored grains [23] . ...

How does Fusarium mycotoxins affect human health? ›

Ingestion of low to moderate amounts of Fusarium mycotoxins is common and generally does not result in obvious intoxication. However, these low amounts may impair intestinal health, immune function and/or pathogen fitness, resulting in altered host pathogen interactions and thus a different outcome of infection.

What is the drug of choice for Fusarium species? ›

Amphotericin B (AmB) is the most active drug followed by voriconazole (VRC) [27,29,30]. Members of the Fusarium fujikuroi species complex (FFSC), which are responsible for approximately one-third of the disseminated infections, display a similar susceptibility profile [25].

What are mycotoxins most closely associated with? ›

Mycotoxins are secondary metabolites of fungi. Many storage fungal species may produce mycotoxins. The most toxigenic storage fungi include members of the genera Aspergillus and Penicillium. Formation of mycotoxins is closely related to mold growth.

What ingredient is susceptible to mycotoxins? ›

Some foods—such as grains, dried beans, dried fruits, and coffee—are susceptible to fungus or mold that produce toxins known as mycotoxins. Only certain molds and fungi can produce mycotoxins of concern. If you eat something containing high levels of those mycotoxins, you can get sick.

Can mycotoxins suppress the immune system? ›

Consumption of some mycotoxins, at levels that do not cause overt clinical mycotoxicosis, suppress immune functions and may decrease resistance to infectious disease.

What is the difference between toxins and mycotoxins? ›

Mycotoxins are produced by fungi as secondary metabolites, while bacterial toxins are produced by bacteria to target host cells. Unlike many bacterial toxins which are proteins, mycotoxins are haptens of low molecular weight that need to be conjugated to a protein before they can be recognized by antibodies.

What is the commonest source of mycotoxins? ›

Key facts. Mycotoxins are naturally occurring toxins produced by certain moulds (fungi) and can be found in food. The moulds grow on a variety of different crops and foodstuffs including cereals, nuts, spices, dried fruits, apples and coffee beans, often under warm and humid conditions.

What is the disadvantage of mycotoxins? ›

Mycotoxins are toxic secondary metabolites produced by fungi when they colonies the foodstuffs. These are potent toxins having severe health consequences in people, being mutagenic, teratogenic, and carcinogenic.

What part of the body do mycotoxins affect? ›

The toxicities of aflatoxins, fumonisins, deoxynivalenol, and ochratoxin A include cytotoxicity, liver cancer, kidney cancer and damage, intestinal barrier function disruption, immune modulation, and poor fetal development, all of which can affect humans.

What are the neurological effects of mold mycotoxins? ›

Mycotoxins have significant toxic effects on the brain as well as the peripheral nervous system. Studies have shown that mycotoxins can cause myelin loss, leading to symptoms similar to multiple sclerosis, chronic inflammatory demyelinating polyneuropathy, and other demyelinating disorders.

What does Fusarium do to humans? ›

Fusarium species cause a broad spectrum of infections in humans, including superficial infections such as keratitis and onychomycosis, as well as locally invasive and disseminated infections [1].

How do mycotoxins leave the body? ›

Ideally, mycotoxins should be filtered out by the liver and then escorted out through urine or stool.

What toxins are produced by Fusarium? ›

Fusarium fungi are common to the soil and produce a range of different toxins, including trichothecenes such as deoxynivalenol (DON), nivalenol (NIV) and T-2 and HT-2 toxins, as well as zearalenone (ZEN) and fumonisins. The formation of the moulds and toxins occur on a variety of different cereal crops.

Which group of fungi does Fusarium belong to? ›

Fusarium is a fungal genus belonging to Phylum Ascomycota, Subphylum Pezizomycotina, Class Sordariomycetes, Order Hypocreales, and Family Nectriaceae. Fusarium is a huge genus in which more than 1,500 species are estimated.

What type of spores does Fusarium produce? ›

Fusarium species can produce three different forms of asexual spores (mitotic), including macroconidia, chlamydospores, and microconidia (Figure 1). These asexual spores are the most efficient means of reproduction and dispersal, and they also act as the main source of plant infection.

What does Fusarium produce? ›

The genus Fusarium is one of the most important mycotoxigenic fungal genera in food and feed. Nearly all species are able to produce mycotoxins of which many are under international regulation. Well-known Fusarium mycotoxins are fumonisins, zearalenone, deoxynivalenol, and additional trichothecenes.

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