trazodone, albuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
trazodone and amiodarone both increase QTc interval. Avoid or Use Alternate Drug.
trazodone and amisulpride both increase QTc interval. Avoid or Use Alternate Drug. ECG monitoring is recommended if coadministered.
amitriptyline and trazodone both increase QTc interval. Avoid or Use Alternate Drug.trazodone and amitriptyline both increase serotonin levels. Avoid or Use Alternate Drug.
amoxapine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.trazodone and amoxapine both increase serotonin levels. Avoid or Use Alternate Drug.
trazodone, amphetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
anagrelide and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
apalutamide will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. Avoid or substitute another drug for these medications when possible. Evaluate for loss of therapeutic effect if medication must be coadministered. Adjust dose according to prescribing information if needed.
apomorphine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
trazodone, arformoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
aripiprazole and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
artemether and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
trazodone and artemether/lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.artemether/lumefantrine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
asenapine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
asenapine transdermal and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
atomoxetine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
bedaquiline and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
trazodone, benzphetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
bosentan will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.
buprenorphine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
buprenorphine buccal and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
buprenorphine subdermal implant and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
buprenorphine transdermal and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
buprenorphine, long-acting injection and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
trazodone increases toxicity of bupropion by unspecified interaction mechanism. Avoid or Use Alternate Drug. May lower seizure threshold; keep bupropion dose as low as possible.
trazodone and buspirone both increase serotonin levels. Avoid or Use Alternate Drug.
trazodone, calcium/magnesium/potassium/sodium oxybates.Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
ceritinib and trazodone both increase QTc interval. Avoid or Use Alternate Drug.ceritinib will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.
chloramphenicol will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.
chloroquine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
chlorpromazine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
citalopram and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
clarithromycin will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.trazodone and clarithromycin both increase QTc interval. Avoid or Use Alternate Drug.
clomipramine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.trazodone and clomipramine both increase serotonin levels. Avoid or Use Alternate Drug.
trazodone decreases effects of clonidine by Other (see comment). Avoid or Use Alternate Drug. Comment: Inhibition of uptake by adrenergic neurons.
clozapine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
cobicistat will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.
conivaptan will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.
crizotinib and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
trazodone and cyclobenzaprine both increase serotonin levels. Avoid or Use Alternate Drug.
degarelix and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
desflurane and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
desipramine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.trazodone and desipramine both increase serotonin levels. Avoid or Use Alternate Drug.
trazodone and desvenlafaxine both increase serotonin levels. Avoid or Use Alternate Drug.
trazodone, dexfenfluramine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
trazodone, dexmethylphenidate. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
trazodone, dextroamphetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
trazodone and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug.
trazodone, diethylpropion. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
trazodone, dobutamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
trazodone and dofetilide both increase QTc interval. Avoid or Use Alternate Drug.
donepezil and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
trazodone, dopamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
trazodone, dopexamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
trazodone and dosulepin both increase serotonin levels. Avoid or Use Alternate Drug.
doxepin and trazodone both increase QTc interval. Avoid or Use Alternate Drug.trazodone and doxepin both increase serotonin levels. Avoid or Use Alternate Drug.
trazodone and dronedarone both increase QTc interval. Avoid or Use Alternate Drug.
trazodone and droperidol both increase QTc interval. Avoid or Use Alternate Drug.
duloxetine and trazodone both increase serotonin levels. Avoid or Use Alternate Drug.
efavirenz and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
eliglustat and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
encorafenib and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
trazodone and entrectinib both increase QTc interval. Avoid or Use Alternate Drug.
trazodone, ephedrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
epinephrine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.trazodone, epinephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
epinephrine racemic and trazodone both increase QTc interval. Avoid or Use Alternate Drug.trazodone, epinephrine racemic. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
eribulin and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
trazodone and erythromycin base both increase QTc interval. Avoid or Use Alternate Drug.
trazodone and erythromycin ethylsuccinate both increase QTc interval. Avoid or Use Alternate Drug.
trazodone and erythromycin lactobionate both increase QTc interval. Avoid or Use Alternate Drug.
trazodone and erythromycin stearate both increase QTc interval. Avoid or Use Alternate Drug.
escitalopram and trazodone both increase serotonin levels. Avoid or Use Alternate Drug.
etravirine will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.
trazodone, fenfluramine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
fexinidazole and trazodone both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval.fexinidazole will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Fexinidazole inhibits CYP3A4. Coadministration may increase risk for adverse effects of CYP3A4 substrates.
fingolimod and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
trazodone and fluconazole both increase QTc interval. Avoid or Use Alternate Drug.
fluoxetine and trazodone both increase serotonin levels. Avoid or Use Alternate Drug.
fluphenazine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
fluvoxamine and trazodone both increase serotonin levels. Avoid or Use Alternate Drug.
trazodone and formoterol both increase QTc interval. Avoid or Use Alternate Drug.trazodone, formoterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
fosamprenavir increases levels of trazodone by decreasing metabolism. Avoid or Use Alternate Drug.
gemifloxacin and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
gilteritinib and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
trazodone and givinostat both increase QTc interval. Avoid or Use Alternate Drug. If unable to avoid coadministration, obtain ECGs when initiating, during concomitant use, and as clinically indicated. Withhold if QTc interval >500 ms or a change from baseline >60 ms.
trazodone and glasdegib both increase QTc interval. Avoid or Use Alternate Drug. If coadministration unavoidable, monitor for increased risk of QTc interval prolongation.
granisetron and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
trazodone decreases effects of guanfacine by Other (see comment). Avoid or Use Alternate Drug. Comment: Inhibition of uptake by adrenergic neurons.
trazodone and haloperidol both increase QTc interval. Avoid or Use Alternate Drug.
hydroxyzine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
idelalisib will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substrates
imipramine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.trazodone and imipramine both increase serotonin levels. Avoid or Use Alternate Drug.
inotuzumab and trazodone both increase QTc interval. Avoid or Use Alternate Drug. If unable to avoid concomitant use, obtain ECGs and electrolytes before and after initiation of any drug known to prolong QTc, and periodically monitor as clinically indicated during treatment.
isoflurane and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
trazodone, isoproterenol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
itraconazole will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.trazodone and itraconazole both increase QTc interval. Avoid or Use Alternate Drug.
ivosidenib will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of sensitive CYP3A4 substrates with ivosidenib or replace with alternative therapies. If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs.
ketoconazole will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.trazodone and ketoconazole both increase QTc interval. Avoid or Use Alternate Drug.
trazodone, levalbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
levoketoconazole will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.trazodone and levoketoconazole both increase QTc interval. Avoid or Use Alternate Drug.
levomilnacipran and trazodone both increase serotonin levels. Avoid or Use Alternate Drug.
linezolid and trazodone both increase serotonin levels. Avoid or Use Alternate Drug. Linezolid may increase serotonin as a result of MAO-A inhibition. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Serotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring, whichever comes first.
trazodone, lisdexamfetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
lithium and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
lofepramine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.trazodone and lofepramine both increase serotonin levels. Avoid or Use Alternate Drug.
trazodone will increase the level or effect of lonafarnib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. If coadministration of lonafarnib (a sensitive CYP3A substrate) with weak CYP3A inhibitors is unavoidable, reduce to, or continue lonafarnib at starting dose. Closely monitor for arrhythmias and events (eg, syncope, heart palpitations) since lonafarnib effect on QT interval is unknown.lonafarnib will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Avoid coadministration with sensitive CYP3A substrates. If coadministration unavoidable, monitor for adverse reactions and reduce CYP3A substrate dose in accordance with product labeling.
lopinavir will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.
trazodone and lorcaserin both increase serotonin levels. Avoid or Use Alternate Drug.
trazodone and lumefantrine both increase QTc interval. Avoid or Use Alternate Drug.
maprotiline and trazodone both increase QTc interval. Avoid or Use Alternate Drug.trazodone and maprotiline both increase serotonin levels. Avoid or Use Alternate Drug.
trazodone and meperidine both increase serotonin levels. Avoid or Use Alternate Drug.
trazodone, metaproterenol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
methylene blue and trazodone both increase serotonin levels. Avoid or Use Alternate Drug. Methylene blue may increase serotonin as a result of MAO-A inhibition. If methylene blue must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Serotonergic therapy may be resumed 24 hours after last methylene blue dose or after 2 weeks of monitoring, whichever comes first.
trazodone, methylenedioxymethamphetamine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
trazodone, midodrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
mifepristone will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.
milnacipran and trazodone both increase serotonin levels. Avoid or Use Alternate Drug.
mirtazapine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
trazodone and moxifloxacin both increase QTc interval. Avoid or Use Alternate Drug.
nefazodone will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.nefazodone and trazodone both increase serotonin levels. Avoid or Use Alternate Drug.
nevirapine will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.
trazodone and nilotinib both increase QTc interval. Avoid or Use Alternate Drug.
trazodone, norepinephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
nortriptyline and trazodone both increase QTc interval. Avoid or Use Alternate Drug.trazodone and nortriptyline both increase serotonin levels. Avoid or Use Alternate Drug.
trazodone and octreotide both increase QTc interval. Avoid or Use Alternate Drug.
trazodone and octreotide (Antidote) both increase QTc interval. Avoid or Use Alternate Drug.
olanzapine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
trazodone and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychom*otor performance and cause daytime impairment.
oxaliplatin and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
ozanimod increases levels of trazodone by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Avoid or Use Alternate Drug. Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis. Therefore, coadministration of ozanimod with drugs that can increase norepinephrine or serotonin is not recommended. Monitor for hypertension with concomitant use.
trazodone and panobinostat both increase QTc interval. Avoid or Use Alternate Drug. Panobinostat is known to significantly prolong QT interval. Panobinostat prescribing information states use with drugs known to prolong QTc is not recommended.
paroxetine and trazodone both increase serotonin levels. Avoid or Use Alternate Drug.
perphenazine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
trazodone, phendimetrazine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
trazodone, phentermine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.trazodone, phentermine.Either increases toxicity of the other by Mechanism: unknown. Avoid or Use Alternate Drug. Risk of serotonin syndrome.
trazodone, phenylephrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
trazodone, phenylephrine PO. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
trazodone, pirbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
trazodone and pitolisant both increase QTc interval. Avoid or Use Alternate Drug.
trazodone decreases levels of pomalidomide by P-glycoprotein (MDR1) efflux transporter. Avoid or Use Alternate Drug.
posaconazole will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.
primaquine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
promazine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
trazodone, propylhexedrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
protriptyline and trazodone both increase QTc interval. Avoid or Use Alternate Drug.trazodone and protriptyline both increase serotonin levels. Avoid or Use Alternate Drug.
trazodone, pseudoephedrine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
rasagiline and trazodone both increase serotonin levels. Avoid or Use Alternate Drug. Trazodone should not be coadministered with a MAOI or within 14 days of discontinuing a MAOI. Similarly, a MAOI should not be given within 14 days of stopping trazodone.
ribociclib will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.
rifabutin will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.
rifampin will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.
rifapentine will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.
trazodone, salmeterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
selegiline and trazodone both increase serotonin levels. Avoid or Use Alternate Drug.
selegiline transdermal and trazodone both increase serotonin levels. Avoid or Use Alternate Drug.
trazodone, serdexmethylphenidate/dexmethylphenidate. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
sertraline and trazodone both increase serotonin levels. Avoid or Use Alternate Drug.sertraline and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
sevoflurane and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
siponimod and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
trazodone, sodium oxybate.Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
solifenacin and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
St John's Wort will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.trazodone and St John's Wort both increase serotonin levels. Avoid or Use Alternate Drug.
sunitinib and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
tacrolimus and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
tedizolid, trazodone.Either increases effects of the other by Mechanism: pharmacodynamic synergism. Avoid or Use Alternate Drug. both increase serotonin levels; increased risk of serotonin syndrome.
trazodone, terbutaline. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
tetrabenazine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
thioridazine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
tipranavir will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.
trazodone and toremifene both increase QTc interval. Avoid or Use Alternate Drug. Concurrent use of toremifene with agents causing QT prolongation should be avoided. If concomitant use is required it's recommended that toremifene be interrupted. If interruption not possible, patients requiring therapy with a drug that prolongs QT should be closely monitored. ECGs should be obtained for high risk patients.
trifluoperazine and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
trazodone and trimipramine both increase QTc interval. Avoid or Use Alternate Drug.trazodone and trimipramine both increase serotonin levels. Avoid or Use Alternate Drug.
tucatinib will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Avoid concomitant use of tucatinib with CYP3A substrates, where minimal concentration changes may lead to serious or life-threatening toxicities. If unavoidable, reduce CYP3A substrate dose according to product labeling.
trazodone and venlafaxine both increase serotonin levels. Avoid or Use Alternate Drug.
trazodone, vilazodone.Either increases toxicity of the other by serotonin levels. Avoid or Use Alternate Drug. Concomitant therapy should be discontinued immediately if signs or symptoms of serotonin syndrome emerge and supportive symptomatic treatment should be initiated.
voriconazole will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.
vorinostat and trazodone both increase QTc interval. Avoid or Use Alternate Drug.
trazodone increases toxicity of vortioxetine by serotonin levels. Avoid or Use Alternate Drug.
voxelotor will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Voxelotor increases systemic exposure of sensitive CYP3A4 substrates. Avoid coadministration with sensitive CYP3A4 substrates with a narrow therapeutic index. Consider dose reduction of the sensitive CYP3A4 substrate(s) if unable to avoid.
trazodone, xylometazoline. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
yohimbe, trazodone. Mechanism: unspecified interaction mechanism. Contraindicated. May cause increase or decrease in blood pressure.
trazodone, yohimbine. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
trazodone and ziprasidone both increase QTc interval. Avoid or Use Alternate Drug.
trazodone, zuranolone.Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration of zuranolone with other CNS depressants may increase impairment of psychom*otor performance or CNS depressant effects. If unavoidable, consider dose reduction. .
trazodone and 5-HTP both increase serotonin levels. Modify Therapy/Monitor Closely.
trazodone, aceclofenac.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
trazodone, acemetacin.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
aclidinium and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.
acrivastine and trazodone both increase sedation. Use Caution/Monitor.
trazodone increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.albuterol and trazodone both increase QTc interval. Use Caution/Monitor.
alfentanil and trazodone both increase sedation. Use Caution/Monitor.
trazodone will decrease the level or effect of aliskiren by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
almotriptan and trazodone both increase serotonin levels. Modify Therapy/Monitor Closely.
alprazolam and trazodone both increase sedation. Use Caution/Monitor.
trazodone will decrease the level or effect of amikacin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
amisulpride and trazodone both increase sedation. Use Caution/Monitor.
trazodone will decrease the level or effect of amitriptyline by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.amitriptyline and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.amitriptyline and trazodone both increase sedation. Use Caution/Monitor.
amobarbital will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.amobarbital and trazodone both increase sedation. Use Caution/Monitor.
amoxapine and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.amoxapine and trazodone both increase sedation. Use Caution/Monitor.
trazodone increases and amphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.trazodone and amphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.trazodone increases effects of amphetamine by unknown mechanism. Use Caution/Monitor.
trazodone and apomorphine both increase sedation. Use Caution/Monitor.
aprepitant will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
trazodone increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.arformoterol and trazodone both increase QTc interval. Use Caution/Monitor.
aripiprazole and trazodone both increase sedation. Use Caution/Monitor.
armodafinil will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.trazodone increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
artemether/lumefantrine will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
asenapine and trazodone both increase sedation. Use Caution/Monitor.
asenapine transdermal and trazodone both increase sedation. Use Caution/Monitor.
trazodone, aspirin.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
trazodone, aspirin rectal.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
trazodone, aspirin/citric acid/sodium bicarbonate.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
atazanavir will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.atazanavir increases levels of trazodone by unspecified interaction mechanism. Use Caution/Monitor.
trazodone will increase the level or effect of atogepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
trazodone will decrease the level or effect of atorvastatin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
atracurium and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.
atropine IV/IM and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.
trazodone will increase the level or effect of avapritinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.avapritinib and trazodone both increase sedation. Use Caution/Monitor.
trazodone increases levels of axitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
azelastine and trazodone both increase sedation. Use Caution/Monitor.
trazodone and azithromycin both increase QTc interval. Use Caution/Monitor.
baclofen and trazodone both increase sedation. Use Caution/Monitor.
trazodone will decrease the level or effect of bazedoxifene/conjugated estrogens by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
belladonna and opium and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.belladonna and opium and trazodone both increase sedation. Use Caution/Monitor.
benperidol and trazodone both increase sedation. Use Caution/Monitor.
benzhydrocodone/acetaminophen, trazodone.Either increases effects of the other by serotonin levels. Use Caution/Monitor. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment.benzhydrocodone/acetaminophen and trazodone both increase sedation. Use Caution/Monitor.
trazodone increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
trazodone will increase the level or effect of brexpiprazole by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Administer a quarter of brexpiprazole dose if coadministered with a moderate CYP2D6 inhibitor PLUS a strong/moderate CYP3A4 inhibitor.brexpiprazole and trazodone both increase sedation. Use Caution/Monitor.
brimonidine and trazodone both increase sedation. Use Caution/Monitor.
brivaracetam and trazodone both increase sedation. Use Caution/Monitor.
brompheniramine and trazodone both increase sedation. Use Caution/Monitor.
budesonide will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.trazodone will decrease the level or effect of budesonide by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
trazodone, bupivacaine implant.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Local anesthetics may increase the risk of developing methemoglobinemia when concurrently exposed to drugs that also cause methemoglobinemia.
buprenorphine and trazodone both increase sedation. Use Caution/Monitor.
buprenorphine buccal and trazodone both increase sedation. Use Caution/Monitor.
trazodone, buprenorphine subdermal implant.Either increases toxicity of the other by serotonin levels. Use Caution/Monitor. Concomitant use could result in life-threatening serotonin syndrome. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation, and during dose adjustment of the serotonergic drug. Discontinue buprenorphine if serotonin syndrome is suspected.buprenorphine subdermal implant and trazodone both increase sedation. Use Caution/Monitor.
buprenorphine transdermal and trazodone both increase sedation. Use Caution/Monitor.
trazodone, buprenorphine, long-acting injection.Either increases toxicity of the other by serotonin levels. Use Caution/Monitor. Concomitant use could result in life-threatening serotonin syndrome. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation, and during dose adjustment of the serotonergic drug. Discontinue buprenorphine if serotonin syndrome is suspected.buprenorphine, long-acting injection and trazodone both increase sedation. Use Caution/Monitor.
butabarbital will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.butabarbital and trazodone both increase sedation. Use Caution/Monitor.
butalbital will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.butalbital and trazodone both increase sedation. Use Caution/Monitor.
butorphanol and trazodone both increase sedation. Use Caution/Monitor.
trazodone increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
carbamazepine will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.trazodone will increase the level or effect of carbamazepine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Monitor plasma levels when used concomitantly
carbinoxamine and trazodone both increase sedation. Use Caution/Monitor.
cariprazine and trazodone both increase sedation. Use Caution/Monitor.
carisoprodol and trazodone both increase sedation. Use Caution/Monitor.
trazodone, celecoxib.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
chloral hydrate and trazodone both increase sedation. Use Caution/Monitor.
chlordiazepoxide and trazodone both increase sedation. Use Caution/Monitor.
chlorpheniramine and trazodone both increase sedation. Use Caution/Monitor.
chlorpromazine and trazodone both increase sedation. Use Caution/Monitor.
chlorzoxazone and trazodone both increase sedation. Use Caution/Monitor.
trazodone, choline magnesium trisalicylate.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
cimetidine will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
cinnarizine and trazodone both increase sedation. Use Caution/Monitor.
citalopram and trazodone both increase serotonin levels. Use Caution/Monitor. Combination may increase risk of serotonin syndrome or neuroleptic malignant syndrome-like reactions.
clemastine and trazodone both increase sedation. Use Caution/Monitor.
clomipramine and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.clomipramine and trazodone both increase sedation. Use Caution/Monitor.
clonazepam and trazodone both increase sedation. Use Caution/Monitor.
clorazepate and trazodone both increase sedation. Use Caution/Monitor.
clozapine and trazodone both increase sedation. Use Caution/Monitor.
cobicistat will increase the level or effect of trazodone by Other (see comment). Use Caution/Monitor. Trazodone is a substrate of CYP3A4 and CYP2D6; cobicistat inhibits CYP3A4 and CYP2D6
trazodone and cocaine topical both increase serotonin levels. Modify Therapy/Monitor Closely.
codeine and trazodone both increase sedation. Use Caution/Monitor.
trazodone will decrease the level or effect of conjugated estrogens by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
trazodone will decrease the level or effect of conjugated estrogens, vagin*l by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
cortisone will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.trazodone will decrease the level or effect of cortisone by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
crizotinib increases levels of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Dose reduction may be needed for coadministered drugs that are predominantly metabolized by CYP3A.
crofelemer increases levels of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Crofelemer has the potential to inhibit CYP3A4 at concentrations expected in the gut; unlikely to inhibit systemically because minimally absorbed.
cyclizine and trazodone both increase sedation. Use Caution/Monitor.
cyclobenzaprine and trazodone both increase sedation. Use Caution/Monitor.
cyclosporine will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
cyproheptadine and trazodone both increase sedation. Use Caution/Monitor.
dabrafenib will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.
dantrolene and trazodone both increase sedation. Use Caution/Monitor.
trazodone and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychom*otor performance and cause daytime impairment.
darifenacin will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
darunavir will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Coadministration with SSRIs, TCAs, or trazodone may require dose titration of antidepressant to desired effect (eg, using the lowest feasible initial or maintenance dose). Monitor for antidepressant response.
dasatinib will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.trazodone and dasatinib both increase QTc interval. Modify Therapy/Monitor Closely.
trazodone will decrease the level or effect of daunorubicin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
trazodone decreases effects of debrisoquine by Other (see comment). Use Caution/Monitor. Comment: Inhibition of uptake by adrenergic neurons.
deferasirox will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
trazodone will decrease the level or effect of deflazacort by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
desflurane and trazodone both increase sedation. Use Caution/Monitor.
desipramine and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.desipramine and trazodone both increase sedation. Use Caution/Monitor.
desloratadine and trazodone both increase sedation. Use Caution/Monitor.
deutetrabenazine and trazodone both increase QTc interval. Use Caution/Monitor. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Certain circ*mstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation).
dexamethasone will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.trazodone will decrease the level or effect of dexamethasone by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
dexchlorpheniramine and trazodone both increase sedation. Use Caution/Monitor.
trazodone increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.trazodone and dexfenfluramine both increase serotonin levels. Modify Therapy/Monitor Closely.
dexmedetomidine and trazodone both increase sedation. Use Caution/Monitor.
trazodone increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
trazodone increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.trazodone and dextroamphetamine both increase serotonin levels. Modify Therapy/Monitor Closely.trazodone increases effects of dextroamphetamine by unknown mechanism. Use Caution/Monitor.
trazodone, dextroamphetamine transdermal.Either increases effects of the other by serotonin levels. Modify Therapy/Monitor Closely. Initiate with lower doses and monitor for signs and symptoms of serotonin syndrome, particularly during initiation or dosage increase. If serotonin syndrome occurs, discontinue dextroamphetamine transdermal and concomitant serotonergic drug(s).
dextromoramide and trazodone both increase sedation. Use Caution/Monitor.
diamorphine and trazodone both increase sedation. Use Caution/Monitor.
diazepam and trazodone both increase sedation. Use Caution/Monitor.
diazepam buccal and trazodone both increase sedation. Use Caution/Monitor.diazepam buccal, trazodone.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.
diazepam intranasal, trazodone.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug.diazepam intranasal and trazodone both increase sedation. Use Caution/Monitor.
trazodone, diclofenac.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
trazodone increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
difelikefalin and trazodone both increase sedation. Use Caution/Monitor.
difenoxin hcl and trazodone both increase sedation. Use Caution/Monitor.
trazodone, diflunisal.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
trazodone will decrease the level or effect of digoxin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.trazodone increases levels of digoxin by unspecified interaction mechanism. Use Caution/Monitor.
trazodone and dihydroergotamine both increase serotonin levels. Modify Therapy/Monitor Closely.
trazodone and dihydroergotamine intranasal both increase serotonin levels. Modify Therapy/Monitor Closely.
diltiazem will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
dimenhydrinate and trazodone both increase sedation. Use Caution/Monitor.
diphenhydramine and trazodone both increase sedation. Use Caution/Monitor.
diphenoxylate hcl and trazodone both increase sedation. Use Caution/Monitor.
dipipanone and trazodone both increase sedation. Use Caution/Monitor.
trazodone increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
trazodone will decrease the level or effect of docetaxel by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
trazodone and dolasetron both increase QTc interval. Modify Therapy/Monitor Closely.
trazodone increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
trazodone increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
doxepin and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.doxepin and trazodone both increase sedation. Use Caution/Monitor.
trazodone will decrease the level or effect of doxorubicin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
trazodone will decrease the level or effect of doxorubicin liposomal by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
doxylamine and trazodone both increase sedation. Use Caution/Monitor.
dronedarone will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
droperidol and trazodone both increase sedation. Use Caution/Monitor.
duvelisib will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Coadministration with duvelisib increases AUC of a sensitive CYP3A4 substrate which may increase the risk of toxicities of these drugs. Consider reducing the dose of the sensitive CYP3A4 substrate and monitor for signs of toxicities of the coadministered sensitive CYP3A substrate.
efavirenz will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
elagolix decreases levels of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Elagolix is a weak-to-moderate CYP3A4 inducer. Monitor CYP3A substrates if coadministered. Consider increasing CYP3A substrate dose if needed.
eletriptan and trazodone both increase serotonin levels. Modify Therapy/Monitor Closely.
elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Cobicistat is a CYP3A4 inhibitor; contraindicated with CYP3A4 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events.
encorafenib, trazodone. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Encorafenib both inhibits and induces CYP3A4 at clinically relevant plasma concentrations. Coadministration of encorafenib with sensitive CYP3A4 substrates may result in increased toxicity or decreased efficacy of these agents.
enzalutamide will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
trazodone increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.trazodone increases effects of ephedrine by unknown mechanism. Use Caution/Monitor.
trazodone increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.trazodone increases effects of epinephrine by unknown mechanism. Use Caution/Monitor.
trazodone increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.trazodone increases effects of epinephrine racemic by unknown mechanism. Use Caution/Monitor.
trazodone and ergotamine both increase serotonin levels. Modify Therapy/Monitor Closely.
erythromycin base will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
erythromycin ethylsuccinate will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
erythromycin lactobionate will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
erythromycin stearate will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
eslicarbazepine acetate will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
estazolam and trazodone both increase sedation. Use Caution/Monitor.
trazodone will decrease the level or effect of estradiol by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
trazodone will decrease the level or effect of estrogens conjugated synthetic by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
trazodone will decrease the level or effect of estropipate by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
eszopiclone and trazodone both increase sedation. Use Caution/Monitor.
trazodone and ethanol both increase sedation. Use Caution/Monitor.
trazodone, etodolac.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
etomidate and trazodone both increase sedation. Use Caution/Monitor.
trazodone will decrease the level or effect of etoposide by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
trazodone will decrease the level or effect of everolimus by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
fedratinib will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Adjust dose of drugs that are CYP3A4 substrates as necessary.
trazodone, fenbufen.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
trazodone increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.trazodone and fenfluramine both increase serotonin levels. Modify Therapy/Monitor Closely.fenfluramine, trazodone.Either increases effects of the other by serotonin levels. Use Caution/Monitor. Coadministration with drugs that increase serotoninergic effects may increase the risk of serotonin syndrome.
trazodone, fenoprofen.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
fentanyl and trazodone both increase sedation. Use Caution/Monitor.
fentanyl intranasal and trazodone both increase sedation. Use Caution/Monitor.
fentanyl iontophoretic transdermal system and trazodone both increase sedation. Use Caution/Monitor.
fentanyl transdermal and trazodone both increase sedation. Use Caution/Monitor.
fentanyl transmucosal and trazodone both increase sedation. Use Caution/Monitor.
trazodone will increase the level or effect of finerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Monitor serum potassium during initiation and dosage adjustment of either finererone or weak CYP3A4 inhibitors. Adjust finererone dosage as needed.
trazodone and flecainide both increase QTc interval. Modify Therapy/Monitor Closely.
trazodone will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Increased flibanserin adverse effects may occur if coadministered with multiple weak CYP3A4 inhibitors.
fluconazole will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
fludrocortisone will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.trazodone will decrease the level or effect of fludrocortisone by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
trazodone and fluoxetine both increase QTc interval. Modify Therapy/Monitor Closely.
fluphenazine and trazodone both increase sedation. Use Caution/Monitor.
flurazepam and trazodone both increase sedation. Use Caution/Monitor.
trazodone, flurbiprofen.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
fluvoxamine and trazodone both increase QTc interval. Modify Therapy/Monitor Closely.
trazodone increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
fosamprenavir will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.
fosaprepitant will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
trazodone and foscarnet both increase QTc interval. Modify Therapy/Monitor Closely.
fosphenytoin will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
trazodone and fostemsavir both increase QTc interval. Use Caution/Monitor. QTc prolongation reported with higher than recommended doses of fostemsavir.
frovatriptan and trazodone both increase serotonin levels. Modify Therapy/Monitor Closely.
gabapentin, trazodone.Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.
gabapentin enacarbil, trazodone.Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.
trazodone and ganaxolone both increase sedation. Use Caution/Monitor.
trazodone and gemtuzumab both increase QTc interval. Use Caution/Monitor.
trazodone will decrease the level or effect of gentamicin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
gepirone and trazodone both increase serotonin levels. Use Caution/Monitor. Monitor for symptoms of serotonin syndrome when gepirone is used gepirone with other drugs that may affect the serotonergic neurotransmitter systems. If serotonin syndrome occurs, consider discontinue gepirone and/or concomitant serotonergic drug.
goserelin increases toxicity of trazodone by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.
grapefruit will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
green tea, trazodone. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.
griseofulvin will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
haloperidol and trazodone both increase sedation. Use Caution/Monitor.
henbane and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.
histrelin increases toxicity of trazodone by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.
homatropine and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.
huperzine A increases and trazodone decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.
hydrocodone, trazodone.Either increases effects of the other by serotonin levels. Use Caution/Monitor. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment.
hydrocortisone will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.trazodone will decrease the level or effect of hydrocortisone by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
hydromorphone and trazodone both increase sedation. Use Caution/Monitor.
hydroxyzine and trazodone both increase sedation. Use Caution/Monitor.
hyoscyamine and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.
hyoscyamine spray and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.
trazodone, ibuprofen.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
trazodone, ibuprofen IV.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
trazodone and iloperidone both increase QTc interval. Modify Therapy/Monitor Closely.iloperidone and trazodone both increase sedation. Use Caution/Monitor.iloperidone increases levels of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Iloperidone is a time-dependent CYP3A inhibitor and may lead to increased plasma levels of drugs predominantly eliminated by CYP3A4.
trazodone will decrease the level or effect of imatinib by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
imipramine and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.imipramine and trazodone both increase sedation. Use Caution/Monitor.
indinavir will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.trazodone will decrease the level or effect of indinavir by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
trazodone, indomethacin.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
ipratropium and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.
trazodone will decrease the level or effect of irinotecan liposomal by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
trazodone will increase the level or effect of isavuconazonium sulfate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
isoniazid will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.trazodone and isoniazid both increase serotonin levels. Modify Therapy/Monitor Closely.
trazodone increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
istradefylline will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Istradefylline 40 mg/day increased peak levels and AUC of CYP3A4 substrates in clinical trials. This effect was not observed with istradefylline 20 mg/day. Consider dose reduction of sensitive CYP3A4 substrates.
trazodone will decrease the level or effect of itraconazole by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
trazodone will decrease the level or effect of ivermectin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
ketamine and trazodone both increase sedation. Use Caution/Monitor.
trazodone, ketoprofen.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
trazodone, ketorolac.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
trazodone, ketorolac intranasal.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
trazodone and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
trazodone and L-tryptophan both increase serotonin levels. Modify Therapy/Monitor Closely.
lapatinib will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.trazodone will decrease the level or effect of lapatinib by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.trazodone and lapatinib both increase QTc interval. Modify Therapy/Monitor Closely.
lasmiditan, trazodone.Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.
trazodone will increase the level or effect of lemborexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Lower nightly dose of lemborexant recommended if coadministered with weak CYP3A4 inhibitors. See drug monograph for specific dosage modification.
lenacapavir will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Lencapavir may increase CYP3A4 substrates initiated within 9 months after last SC dose of lenacapavir, which may increase potential risk of adverse reactions of CYP3A4 substrates.
trazodone and lenvatinib both increase QTc interval. Use Caution/Monitor. Lenvatinib prescribing information recommends monitoring ECG closely when coadministered with QT prolonging drugs.
leuprolide increases toxicity of trazodone by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.
trazodone increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
levetiracetam and trazodone both increase sedation. Use Caution/Monitor.
levocetirizine and trazodone both increase sedation. Use Caution/Monitor.
trazodone and levofloxacin both increase QTc interval. Modify Therapy/Monitor Closely.
levorphanol and trazodone both increase sedation. Use Caution/Monitor.
trazodone will decrease the level or effect of linagliptin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Use of alternative treatments is strongly recommended when linagliptin is to be administered with a P-gp inducer.
trazodone increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
trazodone and lithium both increase serotonin levels. Modify Therapy/Monitor Closely.
lofepramine and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.lofepramine and trazodone both increase sedation. Use Caution/Monitor.
trazodone and lofexidine both increase sedation. Use Caution/Monitor.trazodone decreases effects of lofexidine by unspecified interaction mechanism. Use Caution/Monitor.
trazodone increases levels of lomitapide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Lomitapide dose should not exceed 30 mg/day.
trazodone will decrease the level or effect of loperamide by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
loprazolam and trazodone both increase sedation. Use Caution/Monitor.
loratadine and trazodone both increase sedation. Use Caution/Monitor.
lorazepam and trazodone both increase sedation. Use Caution/Monitor.
lorlatinib will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
lormetazepam and trazodone both increase sedation. Use Caution/Monitor.
trazodone, lornoxicam.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
trazodone will decrease the level or effect of lovastatin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
loxapine and trazodone both increase sedation. Use Caution/Monitor.
loxapine inhaled and trazodone both increase sedation. Use Caution/Monitor.
trazodone and lsd both increase serotonin levels. Modify Therapy/Monitor Closely.
lumateperone and trazodone both increase sedation. Use Caution/Monitor.
lumefantrine will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
lurasidone, trazodone.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.lurasidone and trazodone both increase sedation. Use Caution/Monitor.
maprotiline and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.maprotiline and trazodone both increase sedation. Use Caution/Monitor.
trazodone will decrease the level or effect of maraviroc by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
marijuana will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.trazodone and marijuana both increase sedation. Use Caution/Monitor.
mavorixafor and trazodone both increase QTc interval. Modify Therapy/Monitor Closely. Mavorixafor causes concentration-dependent QTc prolongation. Monitor QTc during treatment in patients with risk factors for QTc prolongation (eg, coadministered medications that increase mavorixafor exposure or other drugs with a high risk to prolong the QTc interval). Mavorixafor dose reduction or discontinuation may be required.
meclizine and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.meclizine and trazodone both increase sedation. Use Caution/Monitor.
trazodone, meclofenamate.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
trazodone, mefenamic acid.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
trazodone and melatonin both increase sedation. Use Caution/Monitor.
trazodone, meloxicam.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
meperidine and trazodone both increase sedation. Use Caution/Monitor.
trazodone and meprobamate both increase sedation. Use Caution/Monitor.
trazodone will decrease the level or effect of mestranol by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
trazodone increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
metaxalone and trazodone both increase sedation. Use Caution/Monitor.
trazodone and methadone both increase QTc interval. Modify Therapy/Monitor Closely.methadone and trazodone both increase sedation. Use Caution/Monitor.
trazodone increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. trazodone increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Significant - Monitor Closely..methamphetamine increases toxicity of trazodone by Other (see comment). Use Caution/Monitor. Comment: Amphetamines may increase the toxicity of serotonin modulators, increasing the risk of serotonin syndrome. .
methocarbamol and trazodone both increase sedation. Use Caution/Monitor.
methohexital and trazodone both increase sedation. Use Caution/Monitor.
methscopolamine and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.
methsuximide and trazodone both increase sedation. Use Caution/Monitor.
trazodone increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
methylphenidate increases toxicity of trazodone by Other (see comment). Modify Therapy/Monitor Closely. Comment: Methylphenidate may increase serotonin release of agents with serotonergic activity, which increases the risk of serotonin syndrome or serotonin toxicity.
methylprednisolone will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.trazodone will decrease the level or effect of methylprednisolone by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
metronidazole will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
miconazole vagin*l will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
midazolam and trazodone both increase sedation. Use Caution/Monitor.
trazodone will increase the level or effect of midazolam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Coadministration of mild CYP3A4 inhibitors with midazolam intranasal may cause higher midazolam systemic exposure, which may prolong sedation.
trazodone increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
mipomersen, trazodone.Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Both drugs have potential to increase hepatic enzymes; monitor LFTs.
trazodone and mirtazapine both increase sedation. Use Caution/Monitor.trazodone and mirtazapine both increase serotonin levels. Modify Therapy/Monitor Closely.
mitotane decreases levels of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments.
trazodone increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
morphine and trazodone both increase sedation. Use Caution/Monitor.trazodone and morphine both increase serotonin levels. Modify Therapy/Monitor Closely.
trazodone and motherwort both increase sedation. Use Caution/Monitor.
trazodone and moxonidine both increase sedation. Use Caution/Monitor.
trazodone and nabilone both increase sedation. Use Caution/Monitor.
trazodone, nabumetone.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
nafcillin will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
nalbuphine and trazodone both increase sedation. Use Caution/Monitor.
trazodone, naproxen.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
naratriptan and trazodone both increase serotonin levels. Modify Therapy/Monitor Closely.
nefopam, trazodone. Mechanism: unspecified interaction mechanism. Use Caution/Monitor. Use combination with caution.
nelfinavir will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.trazodone will decrease the level or effect of nelfinavir by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
trazodone will decrease the level or effect of neomycin PO by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
nifedipine will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
nilotinib will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.trazodone will decrease the level or effect of nilotinib by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
nirmatrelvir will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Adverse reactions of nausea, dizziness, hypotension, and syncope observed following coadministration of trazodone and strong CYP3A4 inhibitors. Consider lower trazodone dose.
nirmatrelvir/ritonavir will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Adverse reactions of nausea, dizziness, hypotension, and syncope observed following coadministration of trazodone and strong CYP3A4 inhibitors. Consider lower trazodone dose.
trazodone increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.trazodone increases effects of norepinephrine by unknown mechanism. Use Caution/Monitor.
nortriptyline and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.nortriptyline and trazodone both increase sedation. Use Caution/Monitor.
trazodone and ofloxacin both increase QTc interval. Modify Therapy/Monitor Closely.
olanzapine and trazodone both increase sedation. Use Caution/Monitor.
trazodone, olanzapine/samidorphan.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Coadministration of diazepam, alcohol, or other CNS acting drugs may potentiate orthostatic hypotension observed with olanzapine. Additive sedation may also occur.
trazodone will increase the level or effect of oliceridine by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. If concomitant use is necessary, may require less frequent oliceridine dosing. Closely monitor for respiratory depression and sedation and titrate subsequent doses accordingly. If inhibitor is discontinued, consider increase oliceridine dosage until stable drug effects are achieved. Monitor for signs of opioid withdrawal. trazodone, oliceridine.Either increases effects of the other by serotonin levels. Modify Therapy/Monitor Closely.
opium tincture and trazodone both increase sedation. Use Caution/Monitor.
trazodone and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.orphenadrine and trazodone both increase sedation. Use Caution/Monitor.
osilodrostat and trazodone both increase QTc interval. Use Caution/Monitor.
oxaliplatin will increase the level or effect of trazodone by Other (see comment). Use Caution/Monitor. Monitor for ECG changes if therapy is initiated in patients with drugs known to prolong QT interval.
trazodone, oxaprozin.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
oxazepam and trazodone both increase sedation. Use Caution/Monitor.
oxcarbazepine will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
oxybutynin and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.
oxybutynin topical and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.
oxybutynin transdermal and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.
oxycodone and trazodone both increase sedation. Use Caution/Monitor.
oxymorphone and trazodone both increase sedation. Use Caution/Monitor.
trazodone will decrease the level or effect of pacl*taxel by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
trazodone will decrease the level or effect of pacl*taxel protein bound by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
trazodone will decrease the level or effect of paliperidone by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.trazodone and paliperidone both increase QTc interval. Modify Therapy/Monitor Closely.paliperidone and trazodone both increase sedation. Use Caution/Monitor.
pancuronium and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.
papaveretum and trazodone both increase sedation. Use Caution/Monitor.
trazodone and papaverine both increase sedation. Use Caution/Monitor.
trazodone, parecoxib.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
trazodone will decrease the level or effect of paromomycin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
trazodone and paroxetine both increase QTc interval. Modify Therapy/Monitor Closely.
trazodone and pazopanib both increase QTc interval. Use Caution/Monitor.
peginterferon alfa 2b, trazodone. Other (see comment). Use Caution/Monitor. Comment: When patients are administered peginterferon alpha-2b with CYP2D6 substrates, the therapeutic effect of these drugs may be altered. Peginterferon alpha-2b may increase or decrease levels of CYP2D6 substrate.
pentazocine and trazodone both increase sedation. Use Caution/Monitor.trazodone and pentazocine both increase serotonin levels. Modify Therapy/Monitor Closely.
pentobarbital will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.pentobarbital and trazodone both increase sedation. Use Caution/Monitor.
perphenazine and trazodone both increase sedation. Use Caution/Monitor.
trazodone increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
phenobarbital will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.phenobarbital and trazodone both increase sedation. Use Caution/Monitor.
trazodone increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
trazodone increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
trazodone, phenylephrine ophthalmic. Other (see comment). Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.
trazodone increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
trazodone and pholcodine both increase sedation. Use Caution/Monitor.
pimozide and trazodone both increase sedation. Use Caution/Monitor.
trazodone increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
trazodone, piroxicam.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
trazodone will decrease the level or effect of posaconazole by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.trazodone and posaconazole both increase QTc interval. Modify Therapy/Monitor Closely.
pralidoxime and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.
trazodone will decrease the level or effect of prednisolone by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
prednisone will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.trazodone will decrease the level or effect of prednisone by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
pregabalin, trazodone.Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.
primidone will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.primidone and trazodone both increase sedation. Use Caution/Monitor.
prochlorperazine and trazodone both increase QTc interval. Use Caution/Monitor.prochlorperazine and trazodone both increase sedation. Use Caution/Monitor.
promethazine and trazodone both increase QTc interval. Use Caution/Monitor.promethazine and trazodone both increase sedation. Use Caution/Monitor.
propantheline and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.
propofol and trazodone both increase sedation. Use Caution/Monitor.
trazodone increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
protriptyline and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.protriptyline and trazodone both increase sedation. Use Caution/Monitor.
quazepam and trazodone both increase sedation. Use Caution/Monitor.
quetiapine and trazodone both increase sedation. Use Caution/Monitor.
quinupristin/dalfopristin will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
trazodone and ramelteon both increase sedation. Use Caution/Monitor.
trazodone and ranolazine both increase QTc interval. Modify Therapy/Monitor Closely.
rapacuronium and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.
remimazolam, trazodone.Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Continuously monitor vital signs during sedation and recovery period if coadministered. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics.
rifabutin decreases levels of trazodone by increasing metabolism. Use Caution/Monitor.
trazodone will decrease the level or effect of risperidone by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.trazodone and risperidone both increase QTc interval. Modify Therapy/Monitor Closely.risperidone and trazodone both increase sedation. Use Caution/Monitor.
ritonavir will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.trazodone will decrease the level or effect of ritonavir by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
rizatriptan and trazodone both increase serotonin levels. Modify Therapy/Monitor Closely.
rocuronium and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.
trazodone will decrease the level or effect of romidepsin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
rucaparib will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Adjust dosage of CYP3A4 substrates, if clinically indicated.
rufinamide will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
trazodone, salicylates (non-asa).Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
trazodone increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
trazodone, salsalate.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
trazodone and SAMe both increase serotonin levels. Modify Therapy/Monitor Closely.
scopolamine and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.
trazodone and scullcap both increase sedation. Use Caution/Monitor.
secobarbital will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.secobarbital and trazodone both increase sedation. Use Caution/Monitor.
sevoflurane and trazodone both increase sedation. Use Caution/Monitor.
trazodone and shepherd's purse both increase sedation. Use Caution/Monitor.
trazodone will decrease the level or effect of silodosin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
trazodone will decrease the level or effect of sirolimus by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
solifenacin and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.
stiripentol, trazodone. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Stiripentol is a CYP3A4 inhibitor and inducer. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. CYP3A4 substrates may require dosage adjustment.
trazodone will decrease the level or effect of streptomycin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
sufentanil and trazodone both increase sedation. Use Caution/Monitor.
sufentanil SL, trazodone.Either increases effects of the other by serotonin levels. Use Caution/Monitor. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment.
trazodone and sulfamethoxazole both increase QTc interval. Modify Therapy/Monitor Closely.
trazodone, sulfasalazine.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
trazodone, sulindac.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
sumatriptan and trazodone both increase serotonin levels. Modify Therapy/Monitor Closely.
sumatriptan intranasal and trazodone both increase serotonin levels. Modify Therapy/Monitor Closely.
trazodone will decrease the level or effect of tacrolimus by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
trazodone increases levels of tamsulosin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
tapentadol and trazodone both increase sedation. Use Caution/Monitor.trazodone and tapentadol both increase serotonin levels. Modify Therapy/Monitor Closely.
tazemetostat will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.trazodone will increase the level or effect of tazemetostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
tecovirimat will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Tecovirimat is a weak CYP3A4 inducer. Monitor sensitive CYP3A4 substrates for effectiveness if coadministered.
trazodone and telavancin both increase QTc interval. Modify Therapy/Monitor Closely.
temazepam and trazodone both increase sedation. Use Caution/Monitor.
trazodone increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
thioridazine and trazodone both increase sedation. Use Caution/Monitor.
thiothixene and trazodone both increase sedation. Use Caution/Monitor.
trazodone will increase the level or effect of tinidazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
tiotropium and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.
trazodone will decrease the level or effect of tobramycin by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
trazodone, tolfenamic acid.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
trazodone, tolmetin.Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
tolterodine and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.
trazodone will decrease the level or effect of tolvaptan by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
topiramate will decrease the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.trazodone and topiramate both increase sedation. Modify Therapy/Monitor Closely.
tramadol and trazodone both increase sedation. Use Caution/Monitor.trazodone and tramadol both increase serotonin levels. Modify Therapy/Monitor Closely.
triazolam and trazodone both increase sedation. Use Caution/Monitor.
triclabendazole and trazodone both increase QTc interval. Use Caution/Monitor.
triclofos and trazodone both increase sedation. Use Caution/Monitor.
trifluoperazine and trazodone both increase sedation. Use Caution/Monitor.
trazodone and trimethoprim both increase QTc interval. Modify Therapy/Monitor Closely.
trazodone and trimipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.trazodone and trimipramine both increase sedation. Use Caution/Monitor.
triprolidine and trazodone both increase sedation. Use Caution/Monitor.
triptorelin increases toxicity of trazodone by QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes.
trazodone and tropisetron both increase QTc interval. Modify Therapy/Monitor Closely.
trospium chloride and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.
valbenazine and trazodone both increase QTc interval. Use Caution/Monitor.
vecuronium and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor.
trazodone and venlafaxine both increase QTc interval. Modify Therapy/Monitor Closely.
verapamil will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
trazodone will decrease the level or effect of vinblastine by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
trazodone will decrease the level or effect of vincristine by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
trazodone will decrease the level or effect of vincristine liposomal by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor.
trazodone and voriconazole both increase QTc interval. Modify Therapy/Monitor Closely.
trazodone increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
trazodone increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
trazodone and ziconotide both increase sedation. Use Caution/Monitor.
ziprasidone and trazodone both increase sedation. Use Caution/Monitor.
zolmitriptan and trazodone both increase serotonin levels. Modify Therapy/Monitor Closely.
trazodone increases effects of acarbose by pharmacodynamic synergism. Minor/Significance Unknown.
acetazolamide will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
trazodone, almotriptan. Mechanism: unknown. Minor/Significance Unknown. Risk of weakness, dyspnea, chest pain.
trazodone will decrease the level or effect of alvimopan by P-glycoprotein (MDR1) efflux transporter. Minor/Significance Unknown.
amobarbital, trazodone. Other (see comment). Minor/Significance Unknown. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs.
anastrozole will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
anticholinergic/sedative combos and trazodone both decrease cholinergic effects/transmission. Minor/Significance Unknown.
trazodone will decrease the level or effect of armodafinil by P-glycoprotein (MDR1) efflux transporter. Minor/Significance Unknown.
trazodone increases levels of atorvastatin by unspecified interaction mechanism. Minor/Significance Unknown.
atropine and trazodone both decrease cholinergic effects/transmission. Minor/Significance Unknown.trazodone increases levels of atropine by unknown mechanism. Minor/Significance Unknown.
trazodone increases levels of atropine IV/IM by unknown mechanism. Minor/Significance Unknown.
bazedoxifene/conjugated estrogens, trazodone. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects.
belladonna alkaloids and trazodone both decrease cholinergic effects/transmission. Minor/Significance Unknown.
benztropine and trazodone both decrease cholinergic effects/transmission. Minor/Significance Unknown.
bethanechol increases and trazodone decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
trazodone decreases effects of brimonidine by pharmacodynamic antagonism. Minor/Significance Unknown.
bumetanide, trazodone. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Possible additive hyponatremia.
butabarbital, trazodone. Other (see comment). Minor/Significance Unknown. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs.
butalbital, trazodone. Other (see comment). Minor/Significance Unknown. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs.
carbachol increases and trazodone decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
carbamazepine decreases levels of trazodone by increasing metabolism. Minor/Significance Unknown.
celandine decreases effects of trazodone by pharmacodynamic antagonism. Minor/Significance Unknown. Based on animal studies.
cevimeline increases and trazodone decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
trazodone, chlorpromazine.Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects.trazodone, chlorpromazine.Either increases levels of the other by decreasing metabolism. Minor/Significance Unknown. Additive anticholinergic effects.
trazodone increases effects of chlorpropamide by pharmacodynamic synergism. Minor/Significance Unknown.
cisatracurium and trazodone both decrease cholinergic effects/transmission. Minor/Significance Unknown.
conjugated estrogens, trazodone. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects.
conjugated estrogens, vagin*l, trazodone. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects.
cyclizine and trazodone both decrease cholinergic effects/transmission. Minor/Significance Unknown.
cyclobenzaprine and trazodone both decrease cholinergic effects/transmission. Minor/Significance Unknown.
cyclophosphamide will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
danazol will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
darifenacin and trazodone both decrease cholinergic effects/transmission. Minor/Significance Unknown.
desflurane, trazodone. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Risk of arrhythmias or hypotension.
dexmethylphenidate increases effects of trazodone by decreasing metabolism. Minor/Significance Unknown.
DHEA, herbal will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
dicyclomine and trazodone both decrease cholinergic effects/transmission. Minor/Significance Unknown.
diphenhydramine and trazodone both decrease cholinergic effects/transmission. Minor/Significance Unknown.
donepezil increases and trazodone decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
drospirenone will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
echothiophate iodide increases and trazodone decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
trazodone, eletriptan. Mechanism: unknown. Minor/Significance Unknown. Risk of weakness, dyspnea, chest pain.
estradiol, trazodone. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects.
estrogens conjugated synthetic, trazodone. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects.
estrogens esterified, trazodone. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects.
estropipate, trazodone. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects.
ethacrynic acid, trazodone. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Possible additive hyponatremia.
ethanol, trazodone.Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. Additive impairment of motor skills.
ethinylestradiol, trazodone. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Oxidative metabolism of TCAs may be decreased by ethinyl estradiol. Increased antidepressant serum concentrations may occur. Potential for increased TCA adverse effects.
trazodone increases levels of ethotoin by unspecified interaction mechanism. Minor/Significance Unknown.
etomidate, trazodone. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Risk of arrhythmias or hypotension.
trazodone and eucalyptus both increase sedation. Minor/Significance Unknown.
fesoterodine and trazodone both decrease cholinergic effects/transmission. Minor/Significance Unknown.
trazodone will decrease the level or effect of fexofenadine by P-glycoprotein (MDR1) efflux transporter. Minor/Significance Unknown.
flavoxate and trazodone both decrease cholinergic effects/transmission. Minor/Significance Unknown.
trazodone, fluphenazine.Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects.trazodone, fluphenazine.Either increases levels of the other by decreasing metabolism. Minor/Significance Unknown. Additive anticholinergic effects.
trazodone increases levels of fosphenytoin by unspecified interaction mechanism. Minor/Significance Unknown.
trazodone, frovatriptan. Mechanism: unknown. Minor/Significance Unknown. Risk of weakness, dyspnea, chest pain.
furosemide, trazodone. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Possible additive hyponatremia.
galantamine increases and trazodone decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
trazodone increases effects of glimepiride by pharmacodynamic synergism. Minor/Significance Unknown.
trazodone increases effects of glipizide by pharmacodynamic synergism. Minor/Significance Unknown.
trazodone increases effects of glyburide by pharmacodynamic synergism. Minor/Significance Unknown.
glycopyrrolate and trazodone both decrease cholinergic effects/transmission. Minor/Significance Unknown.
glycopyrrolate inhaled and trazodone both decrease cholinergic effects/transmission. Minor/Significance Unknown.trazodone increases levels of glycopyrrolate inhaled by unknown mechanism. Minor/Significance Unknown.
hydroxyprogesterone caproate (DSC), trazodone. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects.
trazodone increases effects of insulin aspart by pharmacodynamic synergism. Minor/Significance Unknown.
trazodone increases effects of insulin detemir by pharmacodynamic synergism. Minor/Significance Unknown.
trazodone increases effects of insulin glargine by pharmacodynamic synergism. Minor/Significance Unknown.
trazodone increases effects of insulin glulisine by pharmacodynamic synergism. Minor/Significance Unknown.
trazodone increases effects of insulin lispro by pharmacodynamic synergism. Minor/Significance Unknown.
trazodone increases effects of insulin NPH by pharmacodynamic synergism. Minor/Significance Unknown.
trazodone increases effects of insulin regular human by pharmacodynamic synergism. Minor/Significance Unknown.
isoproterenol, trazodone. Mechanism: unknown. Minor/Significance Unknown. Risk of cardiac arrhythmias.
ketamine, trazodone. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Risk of arrhythmias or hypotension.
larotrectinib will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
lithium, trazodone. Other (see comment). Minor/Significance Unknown. Comment: Risk of neurotoxicity in geriatric pts. Multiple mechanisms involved.trazodone, lithium. Mechanism: unknown. Minor/Significance Unknown. Risk of neurotoxicity.
trazodone will decrease the level or effect of loratadine by P-glycoprotein (MDR1) efflux transporter. Minor/Significance Unknown.
trazodone increases levels of lovastatin by unspecified interaction mechanism. Minor/Significance Unknown.
mestranol, trazodone. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects.
trazodone increases effects of metformin by pharmacodynamic synergism. Minor/Significance Unknown.
trazodone increases effects of miglitol by pharmacodynamic synergism. Minor/Significance Unknown.
trazodone, naratriptan. Mechanism: unknown. Minor/Significance Unknown. Risk of weakness, dyspnea, chest pain.
trazodone increases effects of nateglinide by pharmacodynamic synergism. Minor/Significance Unknown.
neostigmine increases and trazodone decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
panax ginseng increases effects of trazodone by pharmacodynamic synergism. Minor/Significance Unknown.
pentobarbital, trazodone. Other (see comment). Minor/Significance Unknown. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs.
trazodone, perphenazine.Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects.trazodone, perphenazine.Either increases levels of the other by decreasing metabolism. Minor/Significance Unknown. Additive anticholinergic effects.
phenobarbital, trazodone. Other (see comment). Minor/Significance Unknown. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs.
trazodone increases levels of phenytoin by unspecified interaction mechanism. Minor/Significance Unknown.
physostigmine increases and trazodone decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
pilocarpine increases and trazodone decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
trazodone increases effects of pioglitazone by pharmacodynamic synergism. Minor/Significance Unknown.
trazodone increases levels of pitavastatin by unspecified interaction mechanism. Minor/Significance Unknown.
pleurisy root decreases effects of trazodone by unspecified interaction mechanism. Minor/Significance Unknown. Theoretical interaction.
trazodone increases levels of pravastatin by unspecified interaction mechanism. Minor/Significance Unknown.
primidone, trazodone. Other (see comment). Minor/Significance Unknown. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs.
trazodone, prochlorperazine.Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects.trazodone, prochlorperazine.Either increases levels of the other by decreasing metabolism. Minor/Significance Unknown. Additive anticholinergic effects.
progesterone micronized, trazodone. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects.
trazodone, promazine.Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects.trazodone, promazine.Either increases levels of the other by decreasing metabolism. Minor/Significance Unknown. Additive anticholinergic effects.
trazodone, promethazine.Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects.trazodone, promethazine.Either increases levels of the other by decreasing metabolism. Minor/Significance Unknown. Additive anticholinergic effects.
propofol, trazodone. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Risk of arrhythmias or hypotension.
pyridostigmine increases and trazodone decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
trazodone increases effects of repaglinide by pharmacodynamic synergism. Minor/Significance Unknown.
rivastigmine increases and trazodone decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
trazodone, rizatriptan. Mechanism: unknown. Minor/Significance Unknown. Risk of weakness, dyspnea, chest pain.
trazodone increases effects of rosiglitazone by pharmacodynamic synergism. Minor/Significance Unknown.
trazodone increases levels of rosuvastatin by unspecified interaction mechanism. Minor/Significance Unknown.
trazodone will increase the level or effect of ruxolitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
trazodone will increase the level or effect of ruxolitinib topical by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
trazodone and sage both increase sedation. Minor/Significance Unknown.
trazodone increases effects of saxagliptin by pharmacodynamic synergism. Minor/Significance Unknown.
secobarbital, trazodone. Other (see comment). Minor/Significance Unknown. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs.
serdexmethylphenidate/dexmethylphenidate increases effects of trazodone by decreasing metabolism. Minor/Significance Unknown.
sevoflurane, trazodone. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Risk of arrhythmias or hypotension.
trazodone increases levels of simvastatin by unspecified interaction mechanism. Minor/Significance Unknown.
trazodone increases effects of sitagliptin by pharmacodynamic synergism. Minor/Significance Unknown.
succinylcholine increases and trazodone decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Minor/Significance Unknown.
sulfamethoxazole decreases levels of trazodone by unspecified interaction mechanism. Minor/Significance Unknown.
trazodone, sumatriptan. Mechanism: unknown. Minor/Significance Unknown. Risk of weakness, dyspnea, chest pain.
trazodone, sumatriptan intranasal. Mechanism: unknown. Minor/Significance Unknown. Risk of weakness, dyspnea, chest pain.
trazodone, thioridazine.Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects.trazodone, thioridazine.Either increases levels of the other by decreasing metabolism. Minor/Significance Unknown. Additive anticholinergic effects.
trazodone increases effects of tolazamide by pharmacodynamic synergism. Minor/Significance Unknown.
trazodone increases effects of tolbutamide by pharmacodynamic synergism. Minor/Significance Unknown.
torsemide, trazodone. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Possible additive hyponatremia.
trazodone, trifluoperazine.Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. Additive hypotensive effects.trazodone, trifluoperazine.Either increases levels of the other by decreasing metabolism. Minor/Significance Unknown. Additive anticholinergic effects.
trazodone increases effects of vasopressin by pharmacodynamic synergism. Minor/Significance Unknown.
verapamil increases levels of trazodone by decreasing metabolism. Minor/Significance Unknown.
trazodone increases effects of vildagliptin by pharmacodynamic synergism. Minor/Significance Unknown.
zafirlukast will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
trazodone, zolmitriptan. Mechanism: unknown. Minor/Significance Unknown. Risk of weakness, dyspnea, chest pain.
zolpidem, trazodone.Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Additive CNS depression.
